{"id":228,"date":"2026-02-23T06:22:38","date_gmt":"2026-02-22T21:22:38","guid":{"rendered":"https:\/\/website.jikei-neuroscience.com\/?page_id=228"},"modified":"2026-02-28T01:43:08","modified_gmt":"2026-02-27T16:43:08","slug":"%e7%ac%ac55%e5%9b%9e%e6%97%a5%e6%9c%ac%e6%85%a2%e6%80%a7%e7%96%bc%e7%97%9b%e5%ad%a6%e4%bc%9a%e5%85%b1%e5%82%ac%e3%82%b7%e3%83%b3%e3%83%9d%e3%82%b8%e3%82%a6%e3%83%a0","status":"publish","type":"page","link":"https:\/\/website.jikei-neuroscience.com\/?page_id=228","title":{"rendered":"\u7b2c55\u56de\u65e5\u672c\u6162\u6027\u75bc\u75db\u5b66\u4f1a\u5171\u50ac\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0"},"content":{"rendered":"\n<p>\u304c\u3093\u60a3\u8005\u306b\u3082\u3044\u308b\u75db\u899a\u5909\u8abf\u6027\u75bc\u75db\uff5e\u8a55\u4fa1\u3068\u6cbb\u7642\u3092\u8003\u3048\u308b<\/p>\n\n\n\n<p>2026-02-28 \u6f14\u8005\uff1a\u52a0\u85e4\u7dcf\u592b\u3000\u8b1b\u6f14\u30b9\u30e9\u30a4\u30c9\u5f15\u7528\u6587\u732e\u4e00\u89a7<\/p>\n\n\n\n<p>Amanzio, M., Mitsikostas, D. D., Giovannelli, F., Bartoli, M., Cipriani, G. E., &amp; Brown, W. A. (2022). Adverse events of active and placebo groups in SARS-CoV-2 vaccine randomized trials: A systematic review. <em>The Lancet Regional Health &#8211; Europe<\/em>, <em>12<\/em>, 100253. https:\/\/doi.org\/10.1016\/j<\/p>\n\n\n\n<p>Boorman, D. C., Crawford, L. S., Henderson, L. A., &amp; Keay, K. A. (2025). Direct comparisons of neural activity during placebo analgesia and nocebo hyperalgesia between humans and rats. <em>Communications Biology<\/em>, <em>8<\/em>(1). https:\/\/doi.org\/10.1038\/s42003-025-07993-1<\/p>\n\n\n\n<p>Craig, A. D., &amp; Bushnell, M. C. (1994). The Thermal Grill Illusion: Unmasking the Burn of Cold Pain. <em>Science<\/em>, <em>265<\/em>(5169), 252\u2013255. https:\/\/doi.org\/10.1126\/science.8023144<\/p>\n\n\n\n<p>Crawford, L. S., Mills, E. P., Hanson, T., Macey, P. M., Glarin, R., Macefield, V. G., Keay, K. A., &amp; Henderson, L. A. (2021). Brainstem mechanisms of pain modulation: A within-subjects 7T fMRI study of placebo analgesic and nocebo hyperalgesic responses. <em>Journal of Neuroscience<\/em>, <em>41<\/em>(47), 9794\u20139806. https:\/\/doi.org\/10.1523\/JNEUROSCI.0806-21.2021<\/p>\n\n\n\n<p>Danziger, N., Faillenot, I., &amp; Peyron, R. (2009). Can We Share a Pain We Never Felt? Neural Correlates of Empathy in Patients with Congenital Insensitivity to Pain. <em>Neuron<\/em>, <em>61<\/em>(2), 203\u2013212. https:\/\/doi.org\/10.1016\/j.neuron.2008.11.023<\/p>\n\n\n\n<p>Egorova, N., Benedetti, F., Gollub, R. L., &amp; Kong, J. (2020). Between placebo and nocebo: Response to control treatment is mediated by amygdala activity and connectivity. <em>European Journal of Pain (United Kingdom)<\/em>, <em>24<\/em>(3), 580\u2013592. https:\/\/doi.org\/10.1002\/ejp.1510<\/p>\n\n\n\n<p>Fiorio, M., Braga, M., Marotta, A., Villa-S\u00e1nchez, B., Edwards, M. J., Tinazzi, M., &amp; Barbiani, D. (2022). Functional neurological disorder and placebo and nocebo effects: shared mechanisms. <em>Nature Reviews Neurology<\/em>, <em>18<\/em>(10), 624\u2013635. https:\/\/doi.org\/10.1038\/s41582-022-00711-z<\/p>\n\n\n\n<p>Foxen-Craft, E., Bourchtein, E., Kaplan, C., Clauw, D. J., &amp; Scott, E. (2023). Pain Widespreadedness, and Not Primary Pain Location, is Associated with Comorbid Symptoms in Children with Chronic Pain. <em>Clinical Journal of Pain<\/em>, <em>39<\/em>(1), 1\u20137. https:\/\/doi.org\/10.1097\/AJP.0000000000001083<\/p>\n\n\n\n<p>Goebel, A., Krock, E., Gentry, C., Israel, M. R., Jurczak, A., Urbina, C. M., Sandor, K., Vastani, N., Maurer, M., Cuhadar, U., Sensi, S., Nomura, Y., Menezes, J., Baharpoor, A., Brieskorn, L., Sandstr\u00f6m, A., Tour, J., Kadetoff, D., Haglund, L., \u2026 Andersson, D. A. (2021). 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The insula; further observations on its function. <em>Brain<\/em>, <em>78<\/em>(4), 445\u2013470. https:\/\/doi.org\/10.1093\/brain\/78.4.445<\/p>\n\n\n\n<p>Salomons, T. V., Iannetti, G. D., Liang, M., &amp; Wood, J. N. (2016). The \u201cpain matrix\u201d in pain-free individuals. In <em>JAMA Neurology<\/em> (Vol. 73, Number 6, pp. 755\u2013756). American Medical Association. https:\/\/doi.org\/10.1001\/jamaneurol.2016.0653<\/p>\n\n\n\n<p>Sato, N., Takahashi, Y., Sugimura, Y. K., &amp; Kato, F. (2024). Presynaptic inhibition of excitatory synaptic transmission from the calcitonin gene-related peptide-containing parabrachial neurons to the central amygdala in mice \u2013 unexpected influence of systemic inflammation thereon. <em>Journal of Pharmacological Sciences<\/em>, <em>154<\/em>(4), 264\u2013273. https:\/\/doi.org\/10.1016\/j.jphs.2024.02.004<\/p>\n\n\n\n<p>Sugimoto, M., Takahashi, Y., Sugimura, Y. K., Tokunaga, R., Yajima, M., &amp; Kato, F. (2021). Active role of the central amygdala in widespread mechanical sensitization in rats with facial inflammatory pain. <em>Pain<\/em>, <em>162<\/em>(8), 2273\u20132286. https:\/\/doi.org\/10.1097\/j.pain.0000000000002224<\/p>\n\n\n\n<p>Wager, T. D., Atlas, L. Y., Lindquist, M. A., Roy, M., Woo, C.-W., &amp; Kross, E. (2013). An fMRI-Based Neurologic Signature of Physical Pain. <em>New England Journal of Medicine<\/em>, <em>368<\/em>(15), 1388\u20131397. https:\/\/doi.org\/10.1056\/nejmoa1204471<\/p>\n\n\n\n<p>Yajima, M., Sugimoto, M., Sugimura, Y. K., Takahashi, Y., &amp; Kato, F. (2022). Acetaminophen and pregabalin attenuate central sensitization in rodent models of nociplastic widespread pain. <em>Neuropharmacology<\/em>, <em>210<\/em>, 109029. https:\/\/doi.org\/10.1016\/j.neuropharm.2022.109029<\/p>\n\n\n\n<p>Yajima, M., Takahashi, Y., Sugimura, Y. K., &amp; Kato, F. (2023). Pregabalin attenuates long-lasting post-inflammatory nociplastic mechanical sensitization in mice. <em>Neurobiology of Pain<\/em>, <em>13<\/em>. https:\/\/doi.org\/10.1016\/j.ynpai.2023.100131<\/p>\n\n\n\n<p>Yajima, M., Takahashi, Y., Uezono, Y., &amp; Kato, F. (2025). Mirogabalin and pregabalin alleviate nociplastic sensitization induced by chemogenetic activation of the central amygdala neurons in rodents. <em>Journal of Pharmacological Sciences<\/em>, <em>158<\/em>(2), 77\u201383. https:\/\/doi.org\/10.1016\/j.jphs.2025.03.004<\/p>\n\n\n\n<p>Zaki, J., Wager, T. D., Singer, T., Keysers, C., &amp; Gazzola, V. (2016). The Anatomy of Suffering: Understanding the Relationship between Nociceptive and Empathic Pain. In <em>Trends in Cognitive Sciences<\/em> (Vol. 20, Number 4, pp. 249\u2013259). Elsevier Ltd. https:\/\/doi.org\/10.1016\/j.tics.2016.02.003<\/p>\n\n\n\n<p>\u52a0\u85e4\u7dcf\u592b. (2022a). \u306a\u305c,\u3069\u306e\u3088\u3046\u306b\u75db\u899a\u306f\u53ef\u5851\u7684\u306b\u5909\u8abf\u3055\u308c\u3046\u308b\u306e\u304b? \u75db\u899a\u5909\u8abf\u6027\u75bc\u75db\u306e\u751f\u7269\u5b66\u7684\u57fa\u76e4\u3068\u6241\u6843\u4f53\u4e2d\u5fc3\u6838. <em>\u30da\u30a4\u30f3\u30af\u30ea\u30cb\u30c3\u30af<\/em>, <em>43<\/em>(12), 1311\u20131318. http:\/\/search.jamas.or.jp\/link\/ui\/2023085767<\/p>\n\n\n\n<p>\u52a0\u85e4\u7dcf\u592b. (2022b). \u75db\u899a\u5909\u8abf\u6027\u75bc\u75db(nociplastic pain)\u2015 \u75db\u307f\u306e\u7b2c3\u306e\u6a5f\u69cb\u5206\u985e. <em>\u30da\u30a4\u30f3\u30af\u30ea\u30cb\u30c3\u30af<\/em>, <em>43<\/em>(1), 35\u201342. <\/p>\n\n\n\n<p>\u52a0\u85e4\u7dcf\u592b. (2022c). \u75db\u899a\u5909\u8abf\u6027\u75bc\u75db(nociplastic pain)Q &amp; A. <em>\u30da\u30a4\u30f3\u30af\u30ea\u30cb\u30c3\u30af<\/em>, <em>43<\/em>(10), 1023\u20131029. http:\/\/search.jamas.or.jp\/link\/ui\/2022309420<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u304c\u3093\u60a3\u8005\u306b\u3082\u3044\u308b\u75db\u899a\u5909\u8abf\u6027\u75bc\u75db\uff5e\u8a55\u4fa1\u3068\u6cbb\u7642\u3092\u8003\u3048\u308b 2026-02-28 \u6f14\u8005\uff1a&#8230; <a href=\"https:\/\/website.jikei-neuroscience.com\/?page_id=228\" class=\"readmore\">\u7d9a\u304d\u3092\u8aad\u3080<span class=\"screen-reader-text\">\u7b2c55\u56de\u65e5\u672c\u6162\u6027\u75bc\u75db\u5b66\u4f1a\u5171\u50ac\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0<\/span><span class=\"fa fa-angle-double-right\" aria-hidden=\"true\"><\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-228","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/website.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/pages\/228","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/website.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/website.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/website.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/website.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=228"}],"version-history":[{"count":4,"href":"https:\/\/website.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/pages\/228\/revisions"}],"predecessor-version":[{"id":233,"href":"https:\/\/website.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/pages\/228\/revisions\/233"}],"wp:attachment":[{"href":"https:\/\/website.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=228"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}