{"id":228,"date":"2026-02-23T06:22:38","date_gmt":"2026-02-22T21:22:38","guid":{"rendered":"https:\/\/website.jikei-neuroscience.com\/?page_id=228"},"modified":"2026-07-25T05:34:43","modified_gmt":"2026-07-24T20:34:43","slug":"%e7%ac%ac55%e5%9b%9e%e6%97%a5%e6%9c%ac%e6%85%a2%e6%80%a7%e7%96%bc%e7%97%9b%e5%ad%a6%e4%bc%9a%e5%85%b1%e5%82%ac%e3%82%b7%e3%83%b3%e3%83%9d%e3%82%b8%e3%82%a6%e3%83%a0","status":"publish","type":"page","link":"https:\/\/website.jikei-neuroscience.com\/?page_id=228","title":{"rendered":"\u7b2c38\u56de\u65e5\u672c\u75bc\u75db\u6f22\u65b9\u7814\u7a76\u4f1a\u5b66\u8853\u96c6\u4f1a\u7279\u5225\u8b1b\u6f14\u95a2\u9023\u8ad6\u6587"},"content":{"rendered":"\n

Brinjikji W, Luetmer PH, Comstock B, Bresnahan BW, Chen LE, Deyo RA, Halabi S, Turner JA, Avins AL, James K, Wald JT, Kallmes DF, Jarvik JG (2015) Systematic literature review of imaging features of spinal degeneration in asymptomatic populations. American Journal of Neuroradiology 36:811\u2013816.<\/p>\n\n\n\n

Comings DE, Amronin GD (1974) Autosomal dominant insensitivity to pain with hyperplastic myelinopathy and autosomal dominant indifference to pain. Neurology 24:838\u2013838.<\/p>\n\n\n\n

Craig AD, Bushnell MC (1994) The Thermal Grill Illusion: Unmasking the Burn of Cold Pain. Science (1979) 265:252\u2013255.<\/p>\n\n\n\n

Crawford LS, Mills EP, Hanson T, Macey PM, Glarin R, Macefield VG, Keay KA, Henderson LA (2021) Brainstem mechanisms of pain modulation: A within-subjects 7T fMRI study of placebo analgesic and nocebo hyperalgesic responses. Journal of Neuroscience 41:9794\u20139806.<\/p>\n\n\n\n

Danziger N, Faillenot I, Peyron R (2009) Can We Share a Pain We Never Felt? Neural Correlates of Empathy in Patients with Congenital Insensitivity to Pain. Neuron 61:203\u2013212.<\/p>\n\n\n\n

Egorova N, Benedetti F, Gollub RL, Kong J (2020) Between placebo and nocebo: Response to control treatment is mediated by amygdala activity and connectivity. European Journal of Pain (United Kingdom) 24:580\u2013592.<\/p>\n\n\n\n

Finnerup NB, Kuner R, Jensen TS (2021) Neuropathic pain: Frommechanisms to treatment. Physiol Rev 101:259\u2013301.<\/p>\n\n\n\n

Fiorio M, Braga M, Marotta A, Villa-S\u00e1nchez B, Edwards MJ, Tinazzi M, Barbiani D (2022) Functional neurological disorder and placebo and nocebo effects: shared mechanisms. Nat Rev Neurol 18:624\u2013635.<\/p>\n\n\n\n

Hashmi JA, Baliki MN, Huang L, Baria AT, Torbey S, Hermann KM, Schnitzer TJ, Apkarian AV (2013) Shape shifting pain: chronification of back pain shifts brain representation from nociceptive to emotional circuits. Brain 136:2751\u20132768.<\/p>\n\n\n\n

Indo Y (2001) Molecular basis of congenital insensitivity to pain with anhidrosis (CIPA): Mutations and polymorphisms inTRKA (NTRK1) gene encoding the receptor tyrosine kinase for nerve growth factor. Hum Mutat 18:462\u2013471.<\/p>\n\n\n\n

Kaplan CM, Kelleher E, Irani A, Schrepf A, Clauw DJ, Harte SE (2024) Deciphering nociplastic pain: clinical features, risk factors and potential mechanisms. Nat Rev Neurol 20:347\u2013363.<\/p>\n\n\n\n

Kosek E (2024) The concept of nociplastic pain-Where to from here? Pain 165:S50\u2013S57.<\/p>\n\n\n\n

Kosek E, Cohen M, Baron R, Gebhart GF, Mico JA, Rice ASC, Rief W, Sluka AK (2016) Do we need a third mechanistic descriptor for chronic pain states? Pain 157:1382\u20131386.<\/p>\n\n\n\n

Mandonnet V, Obaid S, Descoteaux M, St-Onge E, Devaux B, Lev\u00e9 C, Froelich S, Rheault F, Mandonnet E (2024) Electrostimulation of the white matter of the posterior insula and medial operculum: Perception of vibrations, heat, and pain. Pain 165:565\u2013572.<\/p>\n\n\n\n

Mazzola L, Isnard J, Peyron R, Mauguire F (2012) Stimulation of the human cortex and the experience of pain: Wilder Penfield\u2019s observations revisited. Brain 135:631\u2013640.<\/p>\n\n\n\n

Miyazawa Y, Takahashi Y, Watabe AM, Kato F (2018) Predominant synaptic potentiation and activation in the right central amygdala are independent of bilateral parabrachial activation in the hemilateral trigeminal inflammatory pain model of rats. Mol Pain 14.<\/p>\n\n\n\n

Okuda T, Uchiyama S, Sato N, Sugimura YK, Takahashi Y, Tsuda M, Kato F (2025) The posterior-capsular central amygdala (pCeC) showing synaptic coactivation with nociplastic pain-associated parabrachial neurons in mice. iScience:113001 Available at: https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004225012623.<\/p>\n\n\n\n

Penfield W, Faulk ME (1955) The insula; further observations on its function. Brain 78:445\u2013470.<\/p>\n\n\n\n

Sugimoto M, Takahashi Y, Sugimura YK, Tokunaga R, Yajima M, Kato F (2021a) Active role of the central amygdala in widespread mechanical sensitization in rats with facial inflammatory pain. Pain 162:2273\u20132286.<\/p>\n\n\n\n

Sugimoto M, Takahashi Y, Sugimura YK, Tokunaga R, Yajima M, Kato F (2021b) Active role of the central amygdala in widespread mechanical sensitization in rats with facial inflammatory pain. Pain 162:2273\u20132286.<\/p>\n\n\n\n

Treede RD et al. (2015) A classification of chronic pain for ICD-11. Pain 156:1003\u20131007.<\/p>\n\n\n\n

Tsuda M, Beggs S, Salter MW, Inoue K (2013) Microglia and intractable chronic pain. Glia 61:55\u201361.<\/p>\n\n\n\n

Vachon-Presseau E, T\u00e9treault P, Petre B, Huang L, Berger SE, Torbey S, Baria AT, Mansour AR, Hashmi JA, Griffith JW, Comasco E, Schnitzer TJ, Baliki MN, Apkarian AV (2016) Corticolimbic anatomical characteristics predetermine risk for chronic pain. Brain 139:1958\u20131970.<\/p>\n\n\n\n

Yajima M, Sugimoto M, Sugimura YK, Takahashi Y, Kato F (2022a) Acetaminophen and pregabalin attenuate central sensitization in rodent models of nociplastic widespread pain. Neuropharmacology 210:109029.<\/p>\n\n\n\n

Yajima M, Sugimoto M, Sugimura YK, Takahashi Y, Kato F (2022b) Acetaminophen and pregabalin attenuate central sensitization in rodent models of nociplastic widespread pain. Neuropharmacology 210.<\/p>\n\n\n\n

Yajima M, Takahashi Y, Sugimura YK, Kato F (2023a) Pregabalin attenuates long-lasting post-inflammatory nociplastic mechanical sensitization in mice. Neurobiology of Pain 13.<\/p>\n\n\n\n

Yajima M, Takahashi Y, Sugimura YK, Kato F (2023b) Pregabalin attenuates long-lasting post-inflammatory nociplastic mechanical sensitization in mice. Neurobiology of Pain 13:100131.<\/p>\n\n\n\n

Yajima M, Takahashi Y, Uezono Y, Kato F (2025) Mirogabalin and pregabalin alleviate nociplastic sensitization induced by chemogenetic activation of the central amygdala neurons in rodents. J Pharmacol Sci 158:77\u201383.<\/p>\n\n\n\n

\u65e5\u672c\u8a9e\u7dcf\u8aac<\/h2>\n\n\n\n

\u52a0\u85e4\u7dcf\u592b (2020) \u3010\u4e2d\u67a2\u6027\u611f\u4f5c\u3011\u4e2d\u67a2\u6027\u611f\u4f5c\u306b\u304a\u3051\u308b\u8155\u508d\u6838\u30fb\u6241\u6843\u4f53\u4fb5\u5bb3\u53d7\u5bb9\u30b7\u30b9\u30c6\u30e0\u306e\u5f79\u5272. \u30da\u30a4\u30f3\u30af\u30ea\u30cb\u30c3\u30af 41:1566\u20131575.<\/p>\n\n\n\n

\u52a0\u85e4\u7dcf\u592b (2022a) \u3010\u65e5\u672c\u75db\u307f\u95a2\u9023\u5b66\u4f1a\u9023\u5408\u306e\u767a\u8db3\u3092\u8a18\u5ff5\u3057\u3066\u3011\u75db\u899a\u5909\u8abf\u6027\u75bc\u75db(nociplastic pain)\u3000\u75db\u307f\u306e\u7b2c3\u306e\u6a5f\u69cb\u5206\u985e. \u30da\u30a4\u30f3\u30af\u30ea\u30cb\u30c3\u30af 43:35\u201342.<\/p>\n\n\n\n

\u52a0\u85e4\u7dcf\u592b (2022b) \u3010\u75db\u899a\u5909\u8abf\u6027\u75bc\u75db\u3068\u3057\u3066\u8003\u3048\u308b\u7dda\u7dad\u7b4b\u75db\u75c7\u3011\u75db\u899a\u5909\u8abf\u6027\u75bc\u75db(nociplastic pain)Q &amp;amp; A. \u30da\u30a4\u30f3\u30af\u30ea\u30cb\u30c3\u30af 43:1023\u20131029.<\/p>\n\n\n\n

\u52a0\u85e4\u7dcf\u592b (2022c) \u3010\u75db\u899a\u5909\u8abf\u6027\u75bc\u75db(nociplastic pain)\u3011\u306a\u305c,\u3069\u306e\u3088\u3046\u306b\u75db\u899a\u306f\u53ef\u5851\u7684\u306b\u5909\u8abf\u3055\u308c\u3046\u308b\u306e\u304b?\u3000\u75db\u899a\u5909\u8abf\u6027\u75bc\u75db\u306e\u751f\u7269\u5b66\u7684\u57fa\u76e4\u3068\u6241\u6843\u4f53\u4e2d\u5fc3\u6838. \u30da\u30a4\u30f3\u30af\u30ea\u30cb\u30c3\u30af 43:1311\u20131318.<\/p>\n\n\n\n

\u52a0\u85e4\u7dcf\u592b (2024) \u3010\u75db\u899a\u5909\u8abf\u6027\u75bc\u75db\u306e\u795e\u7d4c\u30e1\u30ab\u30cb\u30ba\u30e0\u3011\u7121\u810a\u690e\u52d5\u7269\u306e\u75db\u899a\u5909\u8abf\u6027\u75bc\u75db\u30005\u5104\u5e74\u306e\u9032\u5316\u3092\u8d85\u3048\u3066. \u30da\u30a4\u30f3\u30af\u30ea\u30cb\u30c3\u30af 45:323\u2013326.<\/p>\n\n\n\n

\u52a0\u85e4\u7dcf\u592b (2025) \u3010\u982d\u75db\u8a3a\u7642\u306e\u65b0\u6f6e\u6d41-\u795e\u7d4c\u79d1\u5b66\u306e\u9032\u6b69\u304c\u3082\u305f\u3089\u3059\u6cbb\u7642\u6226\u7565\u3011\u982d\u75db\u533b\u7642\u306e\u30c8\u30d4\u30c3\u30af\u30b9\u3000\u7247\u982d\u75db\u3068\u75db\u899a\u5909\u8abf\u6027\u75bc\u75db. \u533b\u5b66\u306e\u3042\u3086\u307f 294:435\u2013440.<\/p>\n\n\n\n

\u52a0\u85e4\u7dcf\u592b (2026a) \u75db\u307f\u3068\u306f\u4f55\u304b?\u6700\u65b0\u8133\u79d1\u5b66\u306b\u3088\u3063\u3066\u5207\u308a\u62d3\u304b\u308c\u305f\u65b0\u3057\u3044\u75db\u307f\u89b3. \u81ea\u5f8b\u795e\u7d4c 63:16\u201318.<\/p>\n\n\n\n

\u52a0\u85e4\u7dcf\u592b (2026b) \u3010\u6162\u6027\u75bc\u75db\u306b\u304a\u3051\u308b\u6700\u8fd1\u306e\u8a71\u984c\u3011\u75db\u899a\u5909\u8abf\u6027\u75bc\u75db\u306e\u6700\u8fd1\u306e\u8a71\u984c. \u9ebb\u9154 75:152\u2013160.<\/p>\n\n\n\n

\u52a0\u85e4\u7dcf\u592b, \u9ad8\u6a4b\u7531\u9999\u91cc (2024) \u75db\u899a\u5909\u8abf\u6027\u75bc\u75db\u3000\u65b0\u305f\u306b\u63d0\u5531\u3055\u308c\u305f\u7b2c3\u306e\u75db\u307f\u306e\u30e1\u30ab\u30cb\u30ba\u30e0. \u65e5\u672c\u6b6f\u79d1\u533b\u5e2b\u4f1a\u96d1\u8a8c 77:675\u2013682.<\/p>\n\n\n\n

\u77e2\u5cf6\u611b\u7f8e, \u6749\u672c\u771f\u7406\u5b50, \u52a0\u85e4\u7dcf\u592b (2022) \u4fb5\u5bb3\u53d7\u5bb9\u3068\u795e\u7d4c\u969c\u5bb3\u3092\u3068\u3082\u306a\u308f\u306a\u3044\u75db\u899a\u5909\u8abf\u6027\u5e83\u6c4e\u6027\u75db\u899a\u904e\u654f\u306b\u304a\u3088\u307c\u3059\u4e2d\u67a2\u4f5c\u7528\u6027\u93ae\u75db\u85ac\u306e\u524d\u81e8\u5e8a\u85ac\u52b9\u8a55\u4fa1. \u6162\u6027\u75bc\u75db 41:52\u201360.<\/p>\n\n\n\n

\u9ad8\u6a4b\u7531\u9999\u91cc, \u52a0\u85e4\u7dcf\u592b (2024) \u3010\u75db\u899a\u5909\u8abf\u6027\u75bc\u75db\u306e\u795e\u7d4c\u30e1\u30ab\u30cb\u30ba\u30e0\u3011\u5916\u5074\u8155\u508d\u6838-\u6241\u6843\u4f53\u4e2d\u5fc3\u6838\u30b7\u30b9\u30c6\u30e0\u306e\u53ef\u5851\u6027\u3068\u75db\u899a\u5909\u8abf\u6027\u75bc\u75db. \u30da\u30a4\u30f3\u30af\u30ea\u30cb\u30c3\u30af 45:281\u2013289.<\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Brinjikji W, Luetmer PH, Comstock B, Bre… \u7d9a\u304d\u3092\u8aad\u3080\u7b2c38\u56de\u65e5\u672c\u75bc\u75db\u6f22\u65b9\u7814\u7a76\u4f1a\u5b66\u8853\u96c6\u4f1a\u7279\u5225\u8b1b\u6f14\u95a2\u9023\u8ad6\u6587<\/span><\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-228","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/website.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/pages\/228","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/website.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/website.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/website.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/website.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=228"}],"version-history":[{"count":10,"href":"https:\/\/website.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/pages\/228\/revisions"}],"predecessor-version":[{"id":249,"href":"https:\/\/website.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/pages\/228\/revisions\/249"}],"wp:attachment":[{"href":"https:\/\/website.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=228"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}