第55回日本慢性疼痛学会共催シンポジウム

がん患者にもいる痛覚変調性疼痛~評価と治療を考える

2026-02-28 演者:加藤総夫 講演スライド引用文献一覧

Amanzio, M., Mitsikostas, D. D., Giovannelli, F., Bartoli, M., Cipriani, G. E., & Brown, W. A. (2022). Adverse events of active and placebo groups in SARS-CoV-2 vaccine randomized trials: A systematic review. The Lancet Regional Health – Europe, 12, 100253. https://doi.org/10.1016/j

Boorman, D. C., Crawford, L. S., Henderson, L. A., & Keay, K. A. (2025). Direct comparisons of neural activity during placebo analgesia and nocebo hyperalgesia between humans and rats. Communications Biology, 8(1). https://doi.org/10.1038/s42003-025-07993-1

Craig, A. D., & Bushnell, M. C. (1994). The Thermal Grill Illusion: Unmasking the Burn of Cold Pain. Science, 265(5169), 252–255. https://doi.org/10.1126/science.8023144

Crawford, L. S., Mills, E. P., Hanson, T., Macey, P. M., Glarin, R., Macefield, V. G., Keay, K. A., & Henderson, L. A. (2021). Brainstem mechanisms of pain modulation: A within-subjects 7T fMRI study of placebo analgesic and nocebo hyperalgesic responses. Journal of Neuroscience, 41(47), 9794–9806. https://doi.org/10.1523/JNEUROSCI.0806-21.2021

Danziger, N., Faillenot, I., & Peyron, R. (2009). Can We Share a Pain We Never Felt? Neural Correlates of Empathy in Patients with Congenital Insensitivity to Pain. Neuron, 61(2), 203–212. https://doi.org/10.1016/j.neuron.2008.11.023

Egorova, N., Benedetti, F., Gollub, R. L., & Kong, J. (2020). Between placebo and nocebo: Response to control treatment is mediated by amygdala activity and connectivity. European Journal of Pain (United Kingdom), 24(3), 580–592. https://doi.org/10.1002/ejp.1510

Fiorio, M., Braga, M., Marotta, A., Villa-Sánchez, B., Edwards, M. J., Tinazzi, M., & Barbiani, D. (2022). Functional neurological disorder and placebo and nocebo effects: shared mechanisms. Nature Reviews Neurology, 18(10), 624–635. https://doi.org/10.1038/s41582-022-00711-z

Foxen-Craft, E., Bourchtein, E., Kaplan, C., Clauw, D. J., & Scott, E. (2023). Pain Widespreadedness, and Not Primary Pain Location, is Associated with Comorbid Symptoms in Children with Chronic Pain. Clinical Journal of Pain, 39(1), 1–7. https://doi.org/10.1097/AJP.0000000000001083

Goebel, A., Krock, E., Gentry, C., Israel, M. R., Jurczak, A., Urbina, C. M., Sandor, K., Vastani, N., Maurer, M., Cuhadar, U., Sensi, S., Nomura, Y., Menezes, J., Baharpoor, A., Brieskorn, L., Sandström, A., Tour, J., Kadetoff, D., Haglund, L., … Andersson, D. A. (2021). Passive transfer of fibromyalgia symptoms from patients to mice. Journal of Clinical Investigation, 131(13). https://doi.org/10.1172/JCI144201

Indo, Y. (2001). Molecular basis of congenital insensitivity to pain with anhidrosis (CIPA): Mutations and polymorphisms inTRKA (NTRK1) gene encoding the receptor tyrosine kinase for nerve growth factor. Human Mutation, 18(6), 462–471. https://doi.org/10.1002/humu.1224

Indo, Y. (2014). Neurobiology of pain, interoception and emotional response: Lessons from nerve growth factor-dependent neurons. European Journal of Neuroscience, 39(3), 375–391. https://doi.org/10.1111/ejn.12448

Kaplan, C. M., Kelleher, E., Irani, A., Schrepf, A., Clauw, D. J., & Harte, S. E. (2024). Deciphering nociplastic pain: clinical features, risk factors and potential mechanisms. In Nature Reviews Neurology (Vol. 20, Number 6, pp. 347–363). Nature Research. https://doi.org/10.1038/s41582-024-00966-8

Kosek, E. (2024). The concept of nociplastic pain-Where to from here? Pain, 165(11), S50–S57. https://doi.org/10.1097/j.pain.0000000000003305

Kosek, E., Cohen, M., Baron, R., Gebhart, G. F., Mico, J. A., Rice, A. S. C., Rief, W., & Sluka, A. K. (2016). Do we need a third mechanistic descriptor for chronic pain states? In Pain (Vol. 157, Number 7, pp. 1382–1386). Lippincott Williams and Wilkins. https://doi.org/10.1097/j.pain.0000000000000507

Mandonnet, V., Obaid, S., Descoteaux, M., St-Onge, E., Devaux, B., Levé, C., Froelich, S., Rheault, F., & Mandonnet, E. (2024). Electrostimulation of the white matter of the posterior insula and medial operculum: Perception of vibrations, heat, and pain. Pain, 165(3), 565–572. https://doi.org/10.1097/j.pain.0000000000003069

Mazzola, L., Isnard, J., Peyron, R., & Mauguire, F. (2012). Stimulation of the human cortex and the experience of pain: Wilder Penfield’s observations revisited. Brain, 135(2), 631–640. https://doi.org/10.1093/brain/awr265

Okuda, T., Uchiyama, S., Sato, N., Sugimura, Y. K., Takahashi, Y., Tsuda, M., & Kato, F. (2025). The posterior-capsular central amygdala (pCeC) showing synaptic coactivation with nociplastic pain-associated parabrachial neurons in mice. IScience, 113001. https://doi.org/10.1016/j.isci.2025.113001

Penfield, W., & Faulk, M. E. (1955). The insula; further observations on its function. Brain, 78(4), 445–470. https://doi.org/10.1093/brain/78.4.445

Salomons, T. V., Iannetti, G. D., Liang, M., & Wood, J. N. (2016). The “pain matrix” in pain-free individuals. In JAMA Neurology (Vol. 73, Number 6, pp. 755–756). American Medical Association. https://doi.org/10.1001/jamaneurol.2016.0653

Sato, N., Takahashi, Y., Sugimura, Y. K., & Kato, F. (2024). Presynaptic inhibition of excitatory synaptic transmission from the calcitonin gene-related peptide-containing parabrachial neurons to the central amygdala in mice – unexpected influence of systemic inflammation thereon. Journal of Pharmacological Sciences, 154(4), 264–273. https://doi.org/10.1016/j.jphs.2024.02.004

Sugimoto, M., Takahashi, Y., Sugimura, Y. K., Tokunaga, R., Yajima, M., & Kato, F. (2021). Active role of the central amygdala in widespread mechanical sensitization in rats with facial inflammatory pain. Pain, 162(8), 2273–2286. https://doi.org/10.1097/j.pain.0000000000002224

Wager, T. D., Atlas, L. Y., Lindquist, M. A., Roy, M., Woo, C.-W., & Kross, E. (2013). An fMRI-Based Neurologic Signature of Physical Pain. New England Journal of Medicine, 368(15), 1388–1397. https://doi.org/10.1056/nejmoa1204471

Yajima, M., Sugimoto, M., Sugimura, Y. K., Takahashi, Y., & Kato, F. (2022). Acetaminophen and pregabalin attenuate central sensitization in rodent models of nociplastic widespread pain. Neuropharmacology, 210, 109029. https://doi.org/10.1016/j.neuropharm.2022.109029

Yajima, M., Takahashi, Y., Sugimura, Y. K., & Kato, F. (2023). Pregabalin attenuates long-lasting post-inflammatory nociplastic mechanical sensitization in mice. Neurobiology of Pain, 13. https://doi.org/10.1016/j.ynpai.2023.100131

Yajima, M., Takahashi, Y., Uezono, Y., & Kato, F. (2025). Mirogabalin and pregabalin alleviate nociplastic sensitization induced by chemogenetic activation of the central amygdala neurons in rodents. Journal of Pharmacological Sciences, 158(2), 77–83. https://doi.org/10.1016/j.jphs.2025.03.004

Zaki, J., Wager, T. D., Singer, T., Keysers, C., & Gazzola, V. (2016). The Anatomy of Suffering: Understanding the Relationship between Nociceptive and Empathic Pain. In Trends in Cognitive Sciences (Vol. 20, Number 4, pp. 249–259). Elsevier Ltd. https://doi.org/10.1016/j.tics.2016.02.003

加藤総夫. (2022a). なぜ,どのように痛覚は可塑的に変調されうるのか? 痛覚変調性疼痛の生物学的基盤と扁桃体中心核. ペインクリニック, 43(12), 1311–1318. http://search.jamas.or.jp/link/ui/2023085767

加藤総夫. (2022b). 痛覚変調性疼痛(nociplastic pain)― 痛みの第3の機構分類. ペインクリニック, 43(1), 35–42.

加藤総夫. (2022c). 痛覚変調性疼痛(nociplastic pain)Q & A. ペインクリニック, 43(10), 1023–1029. http://search.jamas.or.jp/link/ui/2022309420